Qi Xu-Feng, Kim Dong-Heui, Yoon Yang-Suk, Li Jian-Hong, Jin Dan, Deung Young-Kun, Lee Kyu-Jae
Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju, Gangwon 220-701, Republic of Korea.
J Ethnopharmacol. 2009 Jun 22;123(2):195-200. doi: 10.1016/j.jep.2009.03.020. Epub 2009 Mar 26.
Bambusae caulis in Liquamen (BCL) is a nutritious liquid extracted from heat-treated fresh bamboo stems. It is an important traditional herbal medicine used to treat coughs and asthma in East Asia. In recent years, it has been studied for its anti-inflammatory, anti-allergenic, and immune-regulating properties.
To examine whether BCL suppresses the development of 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like skin lesions in hairless mice.
The effects of BCL were analyzed by measuring transepidermal water loss (TEWL), melanin content, and erythema in the skin, leukocyte numbers and IgE levels in the serum, and mRNA expression of relevant cytokines in the spleen.
The transdermal administration of BCL to hairless mice inhibited the development of DNCB-induced AD-like skin lesions by suppressing TEWL, melanin production and erythema of skin, the number of leukocytes and the level of IgE in serum, and the mRNA expression of IL-4, IL-13, and TNF-alpha in the spleen. However, BCL administration increased the expression of IFN-gamma in the spleen.
These findings indicate that BCL suppresses the development of DNCB-induced AD-like skin lesions in hairless mice, suggesting that BCL may be a potential therapeutic agent for AD in a clinical setting.
竹沥是从热处理的新鲜竹茎中提取的营养液体。它是东亚用于治疗咳嗽和哮喘的重要传统草药。近年来，对其抗炎、抗过敏和免疫调节特性进行了研究。
研究竹沥是否能抑制2,4-二硝基氯苯（DNCB）诱导的无毛小鼠特应性皮炎（AD）样皮肤损伤的发展。
通过测量皮肤的经表皮水分流失（TEWL）、黑色素含量和红斑、血清中的白细胞数量和IgE水平以及脾脏中相关细胞因子的mRNA表达来分析竹沥的作用。
对无毛小鼠经皮给予竹沥可抑制DNCB诱导的AD样皮肤损伤的发展，其机制包括抑制皮肤的TEWL、黑色素生成和红斑、血清中白细胞数量和IgE水平，以及脾脏中IL-4、IL-13和TNF-α的mRNA表达。然而，给予竹沥会增加脾脏中IFN-γ的表达。
这些发现表明竹沥可抑制DNCB诱导的无毛小鼠AD样皮肤损伤的发展，提示竹沥在临床环境中可能是AD的潜在治疗药物。
