Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
Environ Toxicol Pharmacol. 2012 May;33(3):446-52. doi: 10.1016/j.etap.2012.02.002. Epub 2012 Feb 10.
Platycodi Radix has been used to treat chronic diseases, such as bronchitis, asthma, and hyperlipidemia. In this study, we examined the effect of an aqueous extract, Changkil (CK), from the root of Platycodi Radix on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like skin lesions. Administration of CK onto DNCB-induced AD-like skin lesions in NC/Nga mice ameliorated lesion intensity scores, levels of IgE, thymus and activation-regulated chemokine (TARC), TNF-α, and IL-4 in serum and ears. In contrast, CK increased level of the immunosuppressive cytokine IL-10. Histopathological examination showed reduced thickness of the epidermis/dermis and dermal infiltration of inflammatory cells in the ears. CK also suppressed TNF-α/IFN-γ-induced mRNA expression and production of TARC in HaCaT cells. CK exerts beneficial effects on AD symptoms, suggesting that CK is an effective potential therapeutic agent for AD.
桔梗被用于治疗慢性疾病，如支气管炎、哮喘和高血脂症。在这项研究中，我们研究了桔梗根水提物 Changkil（CK）对 2,4-二硝基氯苯（DNCB）诱导的特应性皮炎（AD）样皮肤损伤的影响。在 NC/Nga 小鼠的 DNCB 诱导的 AD 样皮肤损伤上给予 CK 处理，可改善损伤强度评分、血清和耳部中 IgE、胸腺和激活调节趋化因子（TARC）、TNF-α 和 IL-4 水平。相反，CK 增加了免疫抑制细胞因子 IL-10 的水平。组织病理学检查显示耳部表皮/真皮厚度变薄和炎症细胞浸润减少。CK 还抑制了 TNF-α/IFN-γ 诱导的 HaCaT 细胞中 TARC 的 mRNA 表达和产生。CK 对 AD 症状有有益的影响，表明 CK 是 AD 的一种有效的潜在治疗剂。
