壁磷壁酸可保护金黄色葡萄球菌抵御来自人皮肤的抗菌脂肪酸。
Wall teichoic acid protects Staphylococcus aureus against antimicrobial fatty acids from human skin.
作者信息
Kohler Thomas, Weidenmaier Christopher, Peschel Andreas
机构信息
Cellular and Molecular Microbiology Division, Medical Microbiology and Hygiene Institute, University of Tübingen, Tübingen, Germany.
出版信息
J Bacteriol. 2009 Jul;191(13):4482-4. doi: 10.1128/JB.00221-09. Epub 2009 May 8.
Abstract
Skin-colonizing gram-positive bacteria produce wall teichoic acids (WTAs) or related glycopolymers for unclear reasons. Using a WTA-deficient Staphylococcus aureus mutant, we demonstrated that WTA confers resistance to antimicrobial fatty acids from human sebaceous glands by preventing fatty acid binding. Thus, WTA is probably important for bacterial skin colonization.
摘要
定殖于皮肤的革兰氏阳性菌会产生壁磷壁酸（WTA）或相关糖聚合物，原因不明。我们使用一株缺乏WTA的金黄色葡萄球菌突变体，证明WTA通过阻止脂肪酸结合来赋予对人皮脂腺抗菌脂肪酸的抗性。因此，WTA可能对细菌在皮肤定殖很重要。
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