Cogen A L, Nizet V, Gallo R L
Department of Bioengineering, Division of Dermatology, School of Medicine, University of California, San Diego, CA, USA.
Br J Dermatol. 2008 Mar;158(3):442-55. doi: 10.1111/j.1365-2133.2008.08437.x.
Microbes found on the skin are usually regarded as pathogens, potential pathogens or innocuous symbiotic organisms. Advances in microbiology and immunology are revising our understanding of the molecular mechanisms of microbial virulence and the specific events involved in the host-microbe interaction. Current data contradict some historical classifications of cutaneous microbiota and suggest that these organisms may protect the host, defining them not as simple symbiotic microbes but rather as mutualistic. This review will summarize current information on bacterial skin flora including Staphylococcus, Corynebacterium, Propionibacterium, Streptococcus and Pseudomonas. Specifically, the review will discuss our current understanding of the cutaneous microbiota as well as shifting paradigms in the interpretation of the roles microbes play in skin health and disease.
在皮肤上发现的微生物通常被视为病原体、潜在病原体或无害的共生生物。微生物学和免疫学的进展正在修正我们对微生物毒力分子机制以及宿主-微生物相互作用中涉及的特定事件的理解。目前的数据与皮肤微生物群的一些历史分类相矛盾，并表明这些生物可能保护宿主，这意味着它们并非简单的共生微生物，而是互利共生的。这篇综述将总结有关包括葡萄球菌、棒状杆菌、丙酸杆菌、链球菌和假单胞菌在内的皮肤细菌菌群的当前信息。具体而言，该综述将讨论我们目前对皮肤微生物群的理解，以及在解释微生物在皮肤健康和疾病中所起作用方面不断变化的范式。
