Schöniger S, Summers B A
Department of Pathology and Infectious Disease, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts AL9 7TA, UK.
Vet Pathol. 2009 Sep;46(5):904-15. doi: 10.1354/vp.08-VP-0322-S-FL. Epub 2009 May 9.
In humans, neurofibroma and schwannoma are distinct entities within the group of benign peripheral nerve sheath tumors. In the veterinary literature, these tumors are often classified together simply as benign peripheral nerve sheath tumors, and diagnostic criteria for their subclassification are not well established. We describe peripheral nerve sheath tumors with microscopic, immunohistologic, and ultrastructural features similar to those in subtypes of human neurofibroma in 12 dogs, 2 horses, and 1 chicken. Dogs were of different breeds and were aged 2 months to 15 years. The canine tumors were located in the skin, peripheral nerve, tongue, and large intestine. The 2 horses were 11 and 12 years old. The equine tumors were located in the subcutis of the neck and axilla. The chicken was a mature white Leghorn chicken with an ocular neoplasm. Neurofibromas of this study had localized, plexiform, diffuse and combined plexiform and diffuse growth patterns, and microscopic features similar to those in classic, collagenous, cellular, myxoid, and pigmented neurofibromas of humans. One diffuse neurofibroma contained areas of schwannian differentiation (hybrid neurofibroma-schwannoma). Two plexiform neurofibromas occurred together with diffuse ganglioneuromatosis in the large intestine of young dogs, as has also been reported in humans. This investigation shows the existence of identical subtypes of neurofibroma in animals and humans and identifies similarities in tumor location and patient age between animals and humans. This report will allow a more discriminating classification of benign peripheral nerve sheath tumors and probably has a bearing on epidemiology, pathogenesis and prognosis.
在人类中，神经纤维瘤和神经鞘瘤是良性周围神经鞘瘤组中的不同实体。在兽医文献中，这些肿瘤通常被简单地归为良性周围神经鞘瘤，其亚分类的诊断标准尚未明确确立。我们描述了12只犬、2匹马和1只鸡身上具有与人类神经纤维瘤亚型相似的微观、免疫组织学和超微结构特征的周围神经鞘瘤。犬的品种各异，年龄从2个月到15岁不等。犬的肿瘤位于皮肤、周围神经、舌头和大肠。两匹马分别为11岁和12岁。马的肿瘤位于颈部和腋窝的皮下组织。这只鸡是一只患有眼部肿瘤的成年白色来亨鸡。本研究中的神经纤维瘤具有局限性、丛状、弥漫性以及丛状与弥漫性混合的生长模式，微观特征与人类经典型、胶原型、细胞型、黏液型和色素型神经纤维瘤相似。一个弥漫性神经纤维瘤包含施万细胞分化区域（混合性神经纤维瘤 - 神经鞘瘤）。两只丛状神经纤维瘤与幼犬大肠中的弥漫性神经节细胞瘤同时出现，这在人类中也有报道。这项研究表明动物和人类中存在相同亚型的神经纤维瘤，并确定了动物和人类在肿瘤位置和患者年龄方面的相似性。本报告将有助于对良性周围神经鞘瘤进行更具区分性的分类，可能对流行病学、发病机制和预后有影响。
