Bishop Joshua A, Lou Sha, Schaus Scott E
Department of Chemistry, Center for Chemical Methodology and Library Development at Boston University (CMLD-BU), Life Science and Engineering Building, Boston University, 24 Cummington Street, Boston, MA 02215, USA.
Angew Chem Int Ed Engl. 2009;48(24):4337-40. doi: 10.1002/anie.200901023.
On the big screen: A chiral biphenol catalyst screening protocol was developed for the rapid identification of enantioselective nucleophilic boronate reactions with acyl imines (see scheme). The approach successfully identified a unique catalyst for the reaction of aryl, vinyl, and alkynyl boronates. Mechanistic studies demonstrate boronate ligand exchange with the catalyst is necessary for activation towards nucleophilic addition.
开发了一种手性双酚催化剂筛选方案,用于快速鉴定与酰基亚胺的对映选择性亲核硼酸酯反应(见图)。该方法成功地鉴定出一种用于芳基、乙烯基和炔基硼酸酯反应的独特催化剂。机理研究表明,硼酸酯与催化剂的配体交换对于亲核加成的活化是必要的。