通过与炔丙基碳酸酯的联合交叉偶联实现β-烯丙基硼酸酯的催化对映选择性合成。
Catalytic Enantioselective Synthesis of β-Allenyl Boronic Esters by Conjunctive Cross-Coupling with Propargylic Carbonates.
作者信息
Aparece Mark D, Hu Weipeng, Morken James P
机构信息
Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States.
出版信息
ACS Catal. 2019 Dec 6;9(12):11381-11385. doi: 10.1021/acscatal.9b04453. Epub 2019 Oct 31.
Abstract
Enantioselective conjunctive cross-coupling with propargylic carbonates affords (β-boryl allenes as the reaction product. The reaction is found to proceed through the intermediacy of dimethoxyboronate complexes that are generated in situ by a strain-induced ligand exchange reaction.
摘要
与碳酸炔丙酯的对映选择性联合交叉偶联反应生成(β-硼基丙二烯作为反应产物。发现该反应通过应变诱导的配体交换反应原位生成的二甲氧基硼酸酯配合物中间体进行。
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