Department of Surgical Dentistry, S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Department of Hystology, S.D. Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan.
Int Wound J. 2019 Apr;16(2):343-353. doi: 10.1111/iwj.13034. Epub 2018 Nov 15.
Platelet-rich plasma (PRP) is widely used nowadays in different fields of medicine, affecting physiological processes including tissue regeneration. The use of PRP in maxillofacial surgical interventions and its efficiency in the improvement of postoperative wound healing were analysed. Patients undergoing plastic and reconstructive surgeries in the maxillofacial region were recruited: 50 patients were enrolled into a control group (received no PPRP injection) and 50 patients were enrolled into a treatment group, where PRP was applied during the surgical procedure. Evaluation of treatment outcomes was carried out by determination of IL-1β, TNFα, and IL-6 cytokines levels in the wound-drain fluid. The stages of wound healing were assessed by cytological analyses and ultrasound within a month period. The use of the PRP has substantially positive effects, contributing to the improvement of the healing process. In the treatment group, fibroblasts, macrophages, and collagen fibres appeared and their quantities increased earlier than when compared with control group patients. The concentration of IL-1β and TNFα in wound fluid on day 1 and day 5 after operation was higher for the treatment group as opposed to the control group, which was linked to the influence of PRP on inflammatory and granulation phases of the healing process. An ultrasound examination showed less oedema and infiltration in the tissues around the wound of the treatment group.
富血小板血浆 (PRP) 目前在医学的不同领域得到广泛应用，影响包括组织再生在内的生理过程。分析了 PRP 在颌面外科干预中的应用及其对术后伤口愈合改善的效果。招募接受颌面整形手术的患者：50 名患者纳入对照组（未接受 PRPP 注射），50 名患者纳入治疗组，在手术过程中应用 PRP。通过测定伤口引流液中的 IL-1β、TNFα 和 IL-6 细胞因子水平来评估治疗效果。在一个月的时间内通过细胞学分析和超声检查评估伤口愈合阶段。PRP 的使用具有显著的积极影响，有助于改善愈合过程。在治疗组中，纤维母细胞、巨噬细胞和胶原纤维出现，其数量比对照组患者更早增加。与对照组相比，治疗组术后第 1 天和第 5 天伤口液中 IL-1β 和 TNFα 的浓度更高，这与 PRP 对愈合过程的炎症和肉芽期的影响有关。超声检查显示治疗组伤口周围组织的水肿和浸润程度较低。
