加拿大偏远太平洋沿岸社区第一民族儿童中2型糖尿病、肥胖症及代谢综合征的患病率

Prevalence of type 2 diabetes, obesity and the metabolic syndrome among Canadian First Nations children in a remote Pacific coast community.

作者信息

Wahi Gita, Zorzi Alexandra, Macnab Andrew, Panagiotopoulos Constadina

机构信息

Department of Pediatrics, Endocrinology & Diabetes Unit, University of British Columbia, BC Children's Hospital, Vancouver, British Columbia.

出版信息

Paediatr Child Health. 2009 Feb;14(2):79-83.

PMID:19436466

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2661340/

Abstract

BACKGROUND

Type 2 diabetes mellitus (T2D) in children and adolescents is a growing public health concern. Although the prevalence of T2D in First Nations children has been documented to be as high as 1% in central Canada, no paediatric data are available for any Aboriginal community in British Columbia (BC).

OBJECTIVE

To determine the prevalence of obesity, glucose intolerance and the metabolic syndrome in children living in a remote BC First Nations community.

METHODS

Children who were six to 18 years of age and living in the community of Hartley Bay, BC, participated in the study. A medical history, a physical examination and a 2 h oral glucose tolerance test were completed. Overweight was defined as a body mass index between the 85th and 95th percentiles, and obese was defined as a body mass index greater than or equal to the 95th percentile, which were standardized for age and sex.

RESULTS

Thirty of 34 children (88%) participated (mean +/- SD age 11.8+/-3.4 years). Ten children (33%) were obese, and five (17%) were overweight. There were seven children (23%) with abnormal glucose tolerance as per the 2007 American Diabetes Association criteria: five with only impaired fasting glucose ([IFG] 5.6 mmol/L to 6.9 mmol/L), one with both IFG and impaired glucose tolerance and one with T2D. However, using the 2008 Canadian Diabetes Association criteria, two children (6.7%) had abnormal glucose tolerance (one with IFG plus impaired glucose tolerance and one with T2D) because no child met the definition for IFG alone (6.1 mmol/L to 6.9 mmol/L). Four children (13%) met the criteria for the metabolic syndrome.

CONCLUSIONS

There is a high prevalence of the components of the metabolic syndrome, including overweight, obesity and abnormal glucose tolerance, in the children of this community.

摘要

背景

儿童和青少年2型糖尿病（T2D）日益引起公众健康关注。虽然加拿大中部原住民儿童T2D患病率已被记录高达1%，但不列颠哥伦比亚省（BC）任何原住民社区均无儿科数据。

目的

确定BC省一个偏远原住民社区儿童肥胖、糖耐量异常和代谢综合征的患病率。

方法

6至18岁居住在BC省哈特利湾社区的儿童参与了本研究。完成了病史采集、体格检查和2小时口服葡萄糖耐量试验。超重定义为体重指数处于第85至95百分位之间，肥胖定义为体重指数大于或等于第95百分位，均根据年龄和性别进行了标准化。

结果

34名儿童中有30名（88%）参与（平均±标准差年龄11.8±3.4岁）。10名儿童（33%）肥胖，5名（17%）超重。根据2007年美国糖尿病协会标准，7名儿童（23%）糖耐量异常：5名仅空腹血糖受损（[IFG]5.6 mmol/L至6.9 mmol/L），1名空腹血糖受损且糖耐量受损，1名患T2D。然而，根据2008年加拿大糖尿病协会标准，2名儿童（6.7%）糖耐量异常（1名空腹血糖受损加糖耐量受损，1名患T2D），因为没有儿童符合单独的空腹血糖受损定义（6.1 mmol/L至6.9 mmol/L）。4名儿童（13%）符合代谢综合征标准。