Department of Surgery, University of Santiago de Compostela, Santiago de Compostela, Spain.
Acta Neurochir (Wien). 2010 Mar;152(3):489-91. doi: 10.1007/s00701-009-0366-6. Epub 2009 May 13.
Twiddler syndrome occurs when a patient intentionally or unintentionally manipulates an implantable generator (usually a pacemaker) and dislodges the pacing leads, causing malfunction of the device. Though the syndrome has been described in patients with pacemakers, to our knowledge only one spontaneous case has been described in patients undergoing deep brain stimulation for movement disorders. We report the clinical cases of two patients with Parkinson's disease who had subthalamic bilateral electrodes implanted and presented the twiddler syndrome 2 and 3 years after surgery. We analysed the possible mechanisms of this syndrome and note that twiddler syndrome should be suspected in patients undergoing deep brain stimulation and showing hardware dysfunction.
当患者有意或无意地操纵可植入式发生器（通常是起搏器）并使起搏导线移位时，就会发生 Twiddler 综合征，从而导致设备发生故障。尽管该综合征已在起搏器患者中进行了描述，但据我们所知，在接受深部脑刺激以治疗运动障碍的患者中，仅描述过一例自发性病例。我们报告了两名帕金森病患者的临床病例，他们接受了双侧丘脑底核电极植入，并在手术后 2 年和 3 年出现 Twiddler 综合征。我们分析了这种综合征的可能机制，并指出在接受深部脑刺激且出现硬件功能障碍的患者中应怀疑 Twiddler 综合征。
