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结肠神经鞘细胞错构瘤1例罕见病例

An Unusual Case of Schwann Cell Hamartoma in Colon.

作者信息

Salam Sanna, Abosheaishaa Hazem, Haseeb Ul Rasool Muhammad, Qasim Nimra, Shahzad Ghullamullah

机构信息

Medicine, Queens Hospital Center, New York City, USA.

Internal Medicine, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New York City, USA.

出版信息

Cureus. 2023 May 21;15(5):e39301. doi: 10.7759/cureus.39301. eCollection 2023 May.

DOI:10.7759/cureus.39301
PMID:37346199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10281544/
Abstract

Schwann cell tumors are benign tumors originating from Schwann cells of the peripheral nervous system and are extremely rare in the gastrointestinal system. They usually originate in the colon or rectum but can also occur in the esophagus and small intestine. Their occurrence is rare in GI tract and mainly in the sigmoid colon. Schwann cell tumors have no association with any familial cancer syndromes. We present a 65-year-old female patient who underwent routine colon cancer screening. In addition to open mouth diverticulosis, she was found to have a 3 mm polyp, which was diagnosed as a Schwann cell hamartoma after a biopsy. This study aimed to present this rarely reported case in the literature as an example of a tumor that should be included in the differential diagnosis when considering submucosal colonic lesions. Though the reported reoccurrence rate is low, this case highlights the lack of published guidelines regarding appropriate follow-up surveillance periods.

摘要

施万细胞瘤是起源于周围神经系统施万细胞的良性肿瘤,在胃肠道系统中极为罕见。它们通常起源于结肠或直肠,但也可发生于食管和小肠。其在胃肠道的发生率很低,主要发生在乙状结肠。施万细胞瘤与任何家族性癌症综合征均无关联。我们报告一例65岁女性患者,该患者接受了常规结肠癌筛查。除张口憩室病外,还发现一个3毫米的息肉,活检后诊断为施万细胞错构瘤。本研究旨在展示这一文献中鲜有报道的病例,作为在考虑结肠黏膜下病变时应纳入鉴别诊断的肿瘤实例。尽管报道的复发率较低,但该病例凸显了缺乏关于适当随访监测期的已发表指南的问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/10281544/55908bf872b1/cureus-0015-00000039301-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/10281544/11f8f43611dd/cureus-0015-00000039301-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/10281544/55908bf872b1/cureus-0015-00000039301-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/10281544/11f8f43611dd/cureus-0015-00000039301-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10f7/10281544/55908bf872b1/cureus-0015-00000039301-i02.jpg

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本文引用的文献

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A Rare Case of Schwann Cell Hamartoma in the Duodenum.十二指肠神经鞘细胞错构瘤1例罕见病例
ACG Case Rep J. 2022 Nov 16;9(11):e00894. doi: 10.14309/crj.0000000000000894. eCollection 2022 Nov.
2
Mucosal Schwann cell hamartoma of the gallbladder.胆囊黏膜施万细胞瘤
Autops Case Rep. 2021 Oct 22;11:e2021338. doi: 10.4322/acr.2021.338. eCollection 2021.
3
Mucosal Schwann cell hamartoma of the gastroesophageal junction: A series of 6 cases and comparison with colorectal counterpart.胃食管连接部黏膜神经鞘瘤:6 例系列病例并与结直肠对应物比较。
Ann Diagn Pathol. 2020 Aug;47:151531. doi: 10.1016/j.anndiagpath.2020.151531. Epub 2020 Apr 28.
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Colonic mucosal Schwann cell hamartoma.结肠黏膜施万细胞瘤。
J Dig Dis. 2020 Aug;21(8):475-477. doi: 10.1111/1751-2980.12874. Epub 2020 Jun 11.
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Case of colonic mucosal Schwann cell hamartoma and review of literature on unusual colonic polyps.结肠黏膜施万细胞瘤病例及罕见结肠息肉文献综述
BMJ Case Rep. 2018 Sep 21;2018:bcr-2018-224931. doi: 10.1136/bcr-2018-224931.
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Hamartomatous polyps - a clinical and molecular genetic study.错构瘤性息肉——一项临床与分子遗传学研究
Dan Med J. 2016 Aug;63(8).
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Colonic Mucosal Schwann Cell Hamartoma on Incidental Screening Colonoscopy.结肠镜意外筛查时发现的结肠黏膜施万细胞错构瘤
J Gastrointestin Liver Dis. 2015 Dec;24(4):411. doi: 10.15403/jgld.2014.1121.244.scw.
8
Tactoid body features in a Schwann cell hamartoma of colonic mucosa.结肠黏膜施万细胞错构瘤中的类晶体小体特征。
Int J Surg Pathol. 2014 Aug;22(5):438-41. doi: 10.1177/1066896913501384. Epub 2013 Aug 30.
9
Mucosal schwann cell hamartoma of the colon in a patient with ulcerative colitis.一名溃疡性结肠炎患者的结肠黏膜施万细胞瘤
Gastroenterol Hepatol (N Y). 2013 Mar;9(3):183-5.
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Mucosal schwann-cell hamartoma diagnosed by using an endoscopic snare polypectomy.经内镜圈套息肉切除术诊断的黏膜施万细胞错构瘤
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