通过三溴化铟、炔烃和乙烯基硅基缩醛区域选择性和立体选择性地生成烯基铟化合物。
Regio- and stereoselective generation of alkenylindium compounds from indium tribromide, alkynes, and ketene silyl acetals.
作者信息
Nishimoto Yoshihiro, Moritoh Ryosuke, Yasuda Makoto, Baba Akio
机构信息
Department of Applied Chemistry, Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University, 2-1, Yamada-oka, Suita, Osaka, Japan.
出版信息
Angew Chem Int Ed Engl. 2009;48(25):4577-80. doi: 10.1002/anie.200901417.
PMID:19444849
Abstract
InBr(3) promotes the addition of ketene silyl acetals to monosubstituted alkynes to afford 2,2-disubstituted alkenylindium compounds in high regio- and stereoselectivity (see scheme). In addition, the alkenylindium derivatives have been subsequently coupled with iodobenzene in the presence of a palladium catalyst.
摘要
三溴化铟促进烯酮硅基缩醛与单取代炔烃加成，以高区域和立体选择性得到2,2 -二取代烯基铟化合物（见反应式）。此外，烯基铟衍生物随后在钯催化剂存在下与碘苯发生偶联反应。
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