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吲哚二萜类天然产物作为新合成方法和策略的灵感来源。

Indole diterpenoid natural products as the inspiration for new synthetic methods and strategies.

作者信息

Corsello Michael A, Kim Junyong, Garg Neil K

机构信息

Department of Chemistry and Biochemistry , University of California , Los Angeles , California 90095 , USA . Email:

出版信息

Chem Sci. 2017 Sep 1;8(9):5836-5844. doi: 10.1039/c7sc01248a. Epub 2017 Jun 27.

DOI:10.1039/c7sc01248a
PMID:28970940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5618777/
Abstract

Indole terpenoids comprise a large class of natural products with diverse structural topologies and a broad range of biological activities. Accordingly, indole terpenoids have and continue to serve as attractive targets for chemical synthesis. Many synthetic efforts over the past few years have focused on a subclass of this family, the indole diterpenoids. This minireview showcases the role indole diterpenoids have played in inspiring the recent development of clever synthetic strategies, and new chemical reactions.

摘要

吲哚萜类化合物是一大类天然产物，具有多样的结构拓扑和广泛的生物活性。因此，吲哚萜类化合物一直并将继续成为化学合成的有吸引力的目标。在过去几年中，许多合成工作都集中在这个家族的一个亚类，即吲哚二萜类化合物上。这篇小型综述展示了吲哚二萜类化合物在激发巧妙合成策略和新化学反应的近期发展中所起的作用。

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