McColl Kenneth E L
Medical Sciences, Gardiner Institute, Western Infirmary, Glasgow, Scotland, G11 6NT, UK.
Gastroenterol Clin North Am. 2009 Jun;38(2):353-61. doi: 10.1016/j.gtc.2009.03.004.
The most important clinical point for dyspeptic H pylori-negative NSAID-absent negative ulcers is to adequately ensure that these common risk factors are indeed absent. Once that is done, further investigations to include the rare causes of ulcer disease need to be performed and exclusion of underlying malignancy ensured. The possibility of the Zollinger Ellison syndrome should be considered, remembering that proton pump inhibitor therapy will mitigate its classical, clinical features.
对于消化不良、幽门螺杆菌阴性、未服用非甾体抗炎药的阴性溃疡患者，最重要的临床要点是充分确保这些常见风险因素确实不存在。一旦做到这一点，就需要进一步进行检查，包括排查溃疡病的罕见病因，并确保排除潜在恶性肿瘤。应考虑佐林格-埃利森综合征的可能性，要记住质子泵抑制剂治疗会减轻其典型的临床特征。
