维生素 D 及其类似物在癌症治疗和预防中的有益作用。
The beneficial role of vitamin D and its analogs in cancer treatment and prevention.
机构信息
Vietnamese American Medical Research Foundation, Westminster, CA, USA.
出版信息
Crit Rev Oncol Hematol. 2010 Mar;73(3):192-201. doi: 10.1016/j.critrevonc.2009.04.008. Epub 2009 May 14.
BACKGROUND
Cancer is the leading cause of death in the United States, and the probability of developing cancer increases dramatically with age. Interestingly, vitamin D deficiency is also recognized more often in people of advanced ages. A potential relationship between vitamin D deficiency and cancer has been reported in the literature.
METHOD
Review Medline database literature and discuss the relationship between vitamin D status and cancer.
RESULTS
Environmental (including seasonal and geographic) and genetic factors contribute to the development of both vitamin D deficiency and cancer. The vitamin D receptor is present in many tissues, especially in malignant cells, and may contribute to the successful use of vitamin D and its analogs in the treatment of some cancer patients.
CONCLUSION
Further investigation of the role of vitamin D in the treatment of cancer is warranted.
背景
癌症是美国的主要死因，且癌症的发病概率随年龄的增长而显著增加。有趣的是，维生素 D 缺乏症在高龄人群中也更为常见。文献中已经报道了维生素 D 缺乏症与癌症之间存在潜在关系。
方法
回顾 Medline 数据库中的文献，并讨论维生素 D 状态与癌症之间的关系。
结果
环境因素（包括季节性和地理因素）和遗传因素都会导致维生素 D 缺乏症和癌症的发生。维生素 D 受体存在于许多组织中，特别是在恶性细胞中，这可能有助于维生素 D 及其类似物在治疗某些癌症患者方面的成功应用。
结论
有必要进一步研究维生素 D 在癌症治疗中的作用。
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