Lopes Raíssa do Vale C, Teixeira Juliana A, Marchioni Dirce, Villa Luisa L, Giuliano Anna R, Luiza Baggio Maria, Fisberg Regina M
Department of Nutrition, Faculdade de Saúde Pública, Universidade de São Paulo, Brazil.
Department of Radiology and Oncology, Faculdade de Medicina, Universidade de São Paulo and Center for Translational Research in Oncology, Instituto do Câncer do Estado de São Paulo - ICESP, Brazil.
Int J Cancer. 2017 Aug 15;141(4):757-765. doi: 10.1002/ijc.30772. Epub 2017 May 25.
Human papillomavirus (HPV) infection is a common sexually transmitted disease. Although often transitory, persistent oncogenic HPV infection may progress to a precursor lesion and, if not treated, can further increase the risk of cancer. The purpose of this study was to investigate the relation between dietary intake and HPV persistent infection in men of a Brazilian cohort. The study population consisted of 1,248 men from the Brazilian cohort of the HIM (HPV in Men) Study, ages 18 to 70 years, who completed a quantitative food frequency questionnaire. U Mann-Whitney test was used to assess differences in median nutrient intake of selected nutrients. The association of dietary intake and persistent HPV infection was assessed in multivariate logistic models. The prevalence of any HPV infection at baseline was 66.6%. Of 1,248 participants analyzed, 1,211 (97.0%) were HPV positive at one or more times during the 4 years of follow-up and 781 (62.6%) were persistently HPV positive. Men with nonpersistent oncogenic HPV infections had higher median intake of retinol (p = 0.008), vitamin A (p < 0.001) and folate (DFE; p = 0.003) and lower median intake of energy (p = 0.005) and lycopene (p = 0.008) in comparison to men with persistent oncogenic infections. No significant association was found between selected nutrients and persistent oncogenic HPV infection. For nononcogenic persistent infections, only vitamin B12 intake was significantly associated (p = 0.003, test for trend). No association was observed between dietary intake and persistent oncogenic-type HPV infection; however, vitamin B12 intake was inversely associated with nononcogenic HPV persistence.
人乳头瘤病毒（HPV）感染是一种常见的性传播疾病。尽管通常是短暂的，但持续性致癌性HPV感染可能会发展为前驱病变，若不治疗，会进一步增加患癌风险。本研究的目的是调查巴西队列男性中饮食摄入与HPV持续感染之间的关系。研究人群包括来自男性HPV（HIM）研究巴西队列的1248名男性，年龄在18至70岁之间，他们完成了一份定量食物频率问卷。采用U曼-惠特尼检验来评估所选营养素的中位数摄入量差异。在多变量逻辑模型中评估饮食摄入与HPV持续感染之间的关联。基线时任何HPV感染的患病率为66.6%。在分析的1248名参与者中，1211名（97.0%）在4年随访期间的一次或多次检测中HPV呈阳性，781名（62.6%）持续HPV呈阳性。与持续性致癌性HPV感染的男性相比，非持续性致癌性HPV感染的男性视黄醇（p = 0.008）、维生素A（p < 0.001）和叶酸（膳食叶酸当量；p = 0.003）的中位数摄入量较高，而能量（p = 0.005）和番茄红素（p = 0.008）的中位数摄入量较低。未发现所选营养素与持续性致癌性HPV感染之间存在显著关联。对于非致癌性持续感染，仅维生素B12摄入量与之显著相关（p = 0.003，趋势检验）。未观察到饮食摄入与持续性致癌型HPV感染之间的关联；然而，维生素B12摄入量与非致癌性HPV持续性呈负相关。
