Department of Biology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Environ Pollut. 2009 Aug-Sep;157(8-9):2239-47. doi: 10.1016/j.envpol.2009.04.006. Epub 2009 May 17.
The kinetics of uptake and the effect of body size on uranium (U) bioaccumulation and toxicity to Hyalella azteca exposed to water-only U concentrations in soft water were evaluated. The effect of body size on U bioaccumulation was significant with a slope of -0.35 between log body concentration and log body mass. A saturation kinetic model was satisfactory to describe the uptake rate, elimination rate and the effect of gut-clearance on size-corrected U bioaccumulation in H. azteca. The one-week lethal water concentrations causing 50% mortality for juvenile and adult H. azteca were 1100 and 4000 nmol U/L, respectively. The one-week lethal body concentration causing 50% mortality was 140 nmol U/g for juvenile H. azteca and 220 nmol U/g for adult H. azteca. One-week bioaccumulation studies that properly account for body-size and gut-clearance times can provide valuable data on U bioavailability and toxicity in the environment.
评估了在软水只含有铀（U）浓度的条件下，生物体大小对铀（U）生物累积和毒性的影响以及对其的吸收动力学。生物体大小对 U 生物累积的影响是显著的，其体浓度的对数与体质量的对数之间的斜率为-0.35。吸收速率、消除速率和肠清除对大小校正的 U 在水蚤体内生物累积的影响的描述，采用饱和动力学模型是令人满意的。对幼体和成年水蚤的一周致死水浓度分别为 1100 和 4000 nmol U/L。一周致死的体浓度导致幼体水蚤 50%死亡率为 140 nmol U/g，成年水蚤为 220 nmol U/g。一周的生物累积研究，如果能正确考虑生物体大小和肠清除时间，就可以提供有关环境中 U 的生物有效性和毒性的有价值数据。
