Lubow R E
Department of Psychology, Tel Aviv University, Ramat Aviv 69978, Israel.
Behav Brain Res. 2009 Aug 24;202(1):1-4. doi: 10.1016/j.bbr.2009.03.006. Epub 2009 Mar 19.
There is considerable evidence for the involvement of cerebellar structures and circuits in classical conditioning of eyeblink responses (EBC) and in the pathophyiology of schizophrenia, leading to the expectation that schizophrenia patients should exhibit impaired EBC. A review of the literature indicates that such a position is not supported. Of the nine published studies, three reported poorer EBS in patients compared to controls, three reported better EBC, and three reported no significant EBC differences between the groups. Overall, medicated schizophrenia patients showed poorer EBC, and non-medicated patients exhibited better or normal EBC, relative to healthy control groups. In the light of those results and the fact that no experiment explicitly compared medicated and non-medicated patients, one cannot assume that the EBC deficits in patient groups are attributable to anything other than an effect from medication.
有大量证据表明，小脑结构和神经回路参与眨眼反应（EBC）的经典条件反射以及精神分裂症的病理生理学过程，这使得人们预期精神分裂症患者的EBC会受损。对文献的综述表明，这一观点并不成立。在已发表的九项研究中，三项研究报告称患者的EBS比对照组差，三项研究报告称患者的EBC更好，还有三项研究报告称两组之间的EBC没有显著差异。总体而言，与健康对照组相比，服用药物的精神分裂症患者的EBC较差，而未服用药物的患者则表现出较好或正常的EBC。鉴于这些结果以及没有实验明确比较服用药物和未服用药物的患者这一事实，人们不能假定患者组中EBC的缺陷是由药物以外的任何因素导致的。
