Brown S M, Kieffaber P D, Carroll C A, Vohs J L, Tracy J A, Shekhar A, O'Donnell B F, Steinmetz J E, Hetrick W P
Department of Psychology, Indiana University, 1101 East Tenth Street, Bloomington, IN 47405, USA.
Brain Cogn. 2005 Jun;58(1):94-108. doi: 10.1016/j.bandc.2004.09.011. Epub 2005 Jan 4.
Accumulating evidence indicates that individuals with schizophrenia manifest abnormalities in structures (cerebellum and basal ganglia) and neurotransmitter systems (dopamine) linked to internal-timing processes. A single-cue tone delay eyeblink conditioning paradigm comprised of 100 learning and 50 extinction trials was used to examine cerebellar timing circuits in 13 medicated patients with schizophrenia and 13 age- and sex-matched controls. Patients with schizophrenia showed impaired learning of the conditioned response compared to controls and also greater within-subject variability in the timing of their responses. These findings are consistent with models of schizophrenia in which timing deficits underlie information-processing abnormalities and clinical features of the disorder.
越来越多的证据表明，精神分裂症患者在与内部计时过程相关的结构（小脑和基底神经节）和神经递质系统（多巴胺）中表现出异常。采用由100次学习试验和50次消退试验组成的单线索纯音延迟眨眼条件反射范式，对13名正在服药的精神分裂症患者和13名年龄及性别匹配的对照组进行小脑计时回路检测。与对照组相比，精神分裂症患者在条件反应学习方面受损，并且其反应时间在个体内部的变异性也更大。这些发现与精神分裂症模型一致，在该模型中，计时缺陷是该疾病信息处理异常和临床特征的基础。
