Miranda María Isabel, Ortiz-Godina Fatima, García Dafne
Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Juriquilla, Querétaro, Mexico.
Behav Brain Res. 2009 Aug 24;202(1):19-25. doi: 10.1016/j.bbr.2009.03.008. Epub 2009 Mar 19.
Acetylcholine and norepinephrine have been implicated during different kinds of social recognition that involves olfactory memory formation. For example, blockade of muscarinic and beta-adrenergic receptors has been shown to impair short-term memory of both socially relevant as well as of neutral odors. However, previous studies have not explicitly compared the role of cholinergic and adrenergic modulation in long-term memory for socially relevant odor vs. incidental odor stimuli. In this work, we studied the function of muscarinic and beta-adrenergic receptors during acquisition and/or consolidation of a novel odor and during the retrieval of a familiar odor. The effects of systemic injections of scopolamine and propranolol, before and after presentation of estrous urine odor or mint odor, were evaluated by a long-term odor habituation task. The results demonstrated that scopolamine disrupts memory acquisition and/or consolidation of mint odor, and did not have any effect during retrieval of mint odor memory. Conversely, scopolamine disrupts memory consolidation and retrieval of estrous odor, depending on the dose applied. Propranolol injections have no effect on acquisition or consolidation for mint or estrous odor, but disrupt memory retrieval of familiar odor regarding their social/sexual or neutral content. These results demonstrate that muscarinic receptors are required differentially during long-term odor memory formation and for familiar odor recognition depending on the socially relevant content of the stimulus. Furthermore, the beta-adrenergic system could play an important role in memory recognition for familiar odors, regardless of the sexual/social or neutral content of the stimuli.
乙酰胆碱和去甲肾上腺素在涉及嗅觉记忆形成的不同类型社会识别过程中发挥作用。例如，已表明阻断毒蕈碱受体和β-肾上腺素能受体可损害对社会相关气味以及中性气味的短期记忆。然而，先前的研究并未明确比较胆碱能和肾上腺素能调节在对社会相关气味与偶然气味刺激的长期记忆中的作用。在这项研究中，我们研究了毒蕈碱受体和β-肾上腺素能受体在新气味获取和/或巩固过程以及熟悉气味检索过程中的功能。通过长期气味习惯化任务评估了在呈现发情期尿液气味或薄荷气味之前和之后全身注射东莨菪碱和普萘洛尔的效果。结果表明，东莨菪碱会破坏薄荷气味的记忆获取和/或巩固，而在薄荷气味记忆检索过程中没有任何影响。相反，根据所用剂量，东莨菪碱会破坏发情期气味的记忆巩固和检索。普萘洛尔注射对薄荷或发情期气味的获取或巩固没有影响，但会破坏对熟悉气味的社会/性或中性内容的记忆检索。这些结果表明，在长期气味记忆形成过程中以及根据刺激的社会相关内容进行熟悉气味识别时，毒蕈碱受体的需求存在差异。此外，无论刺激的性/社会或中性内容如何，β-肾上腺素能系统在熟悉气味的记忆识别中可能发挥重要作用。
