Garrido Zinn Carolina, Clairis Nicolas, Silva Cavalcante Lorena Evelyn, Furini Cristiane Regina Guerino, de Carvalho Myskiw Jociane, Izquierdo Ivan
Memory Center, Brain Institute of Rio Grande do Sul, Pontifical Catholic University of Rio Grande do Sul, 90610-000 Porto Alegre, RS, Brazil;
Département de Biologie, Ecole Normale Supérieure de Lyon, 69007 Lyon, France.
Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):E4914-9. doi: 10.1073/pnas.1609883113. Epub 2016 Aug 1.
Social recognition memory (SRM) is crucial for reproduction, forming social groups, and species survival. Despite its importance, SRM is still relatively little studied. Here we examine the participation of the CA1 region of the dorsal hippocampus (CA1) and the basolateral amygdala (BLA) and that of dopaminergic, noradrenergic, and histaminergic systems in both structures in the consolidation of SRM. Male Wistar rats received intra-CA1 or intra-BLA infusions of different drugs immediately after the sample phase of a social discrimination task and 24-h later were subjected to a 5-min retention test. Animals treated with the protein synthesis inhibitor, anisomycin, into either the CA1 or BLA were unable to recognize the previously exposed juvenile (familiar) during the retention test. When infused into the CA1, the β-adrenoreceptor agonist, isoproterenol, the D1/D5 dopaminergic receptor antagonist, SCH23390, and the H2 histaminergic receptor antagonist, ranitidine, also hindered the recognition of the familiar juvenile 24-h later. The latter drug effects were more intense in the CA1 than in the BLA. When infused into the BLA, the β-adrenoreceptor antagonist, timolol, the D1/D5 dopamine receptor agonist, SKF38393, and the H2 histaminergic receptor agonist, ranitidine, also hindered recognition of the familiar juvenile 24-h later. In all cases, the impairment to recognize the familiar juvenile was abolished by the coinfusion of agonist plus antagonist. Clearly, both the CA1 and BLA, probably in that order, play major roles in the consolidation of SRM, but these roles are different in each structure vis-à-vis the involvement of the β-noradrenergic, D1/D5-dopaminergic, and H2-histaminergic receptors therein.
社会识别记忆（SRM）对于繁殖、形成社会群体以及物种生存至关重要。尽管其重要性，但SRM仍相对较少被研究。在此，我们研究背侧海马体（CA1）的CA1区域和基底外侧杏仁核（BLA）以及这两个结构中多巴胺能、去甲肾上腺素能和组胺能系统在SRM巩固过程中的参与情况。雄性Wistar大鼠在社会辨别任务的样本阶段后立即接受不同药物的CA1内或BLA内注射，24小时后进行5分钟的记忆保持测试。在CA1或BLA中注射蛋白质合成抑制剂茴香霉素的动物在记忆保持测试中无法识别先前接触过的幼崽（熟悉的）。当注射到CA1中时，β-肾上腺素能受体激动剂异丙肾上腺素、D1/D5多巴胺能受体拮抗剂SCH23390和H2组胺能受体拮抗剂雷尼替丁，也会在24小时后阻碍对熟悉幼崽的识别。后一种药物效应在CA1中比在BLA中更强烈。当注射到BLA中时，β-肾上腺素能受体拮抗剂噻吗洛尔、D1/D5多巴胺受体激动剂SKF38393和H2组胺能受体激动剂雷尼替丁，也会在24小时后阻碍对熟悉幼崽的识别。在所有情况下，激动剂加拮抗剂的共同注射消除了对熟悉幼崽识别的损害。显然，CA1和BLA可能按此顺序在SRM的巩固中起主要作用，但就β-去甲肾上腺素能、D1/D5-多巴胺能和H2-组胺能受体在其中的参与而言，这些作用在每个结构中是不同的。
