English Amber R, Zurek Nesia, Voeltz Gia K
Department of Molecular, Cellular, & Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
Curr Opin Cell Biol. 2009 Aug;21(4):596-602. doi: 10.1016/j.ceb.2009.04.004. Epub 2009 May 15.
The endoplasmic reticulum (ER) is a single continuous membrane-enclosed organelle made up of functionally and structurally distinct domains. The ER domains include the nuclear envelope (NE) and the peripheral ER, which is a network of tubules and sheets spread throughout the cytoplasm. The structural organization of the ER is related to its many different cellular functions. Here we will discuss how the various functional domains of the peripheral ER are organized into structurally distinct domains that exist within the continuous membrane bilayer throughout the cell cycle. In addition, we will summarize our current knowledge on how peripheral ER membranes contact various other regions of the cytoplasm including the cytoskeleton, mitochondria, Golgi, and the plasma membrane and what is known about the functions of these interactions.
内质网（ER）是一个由功能和结构不同的区域组成的单一连续膜包被细胞器。内质网区域包括核膜（NE）和外周内质网，外周内质网是遍布细胞质的小管和片层网络。内质网的结构组织与其多种不同的细胞功能相关。在这里，我们将讨论外周内质网的各种功能域如何组织成在整个细胞周期中存在于连续膜双层内的结构不同的区域。此外，我们将总结我们目前关于外周内质网膜如何与细胞质的其他各种区域接触的知识，包括细胞骨架、线粒体、高尔基体和质膜，以及关于这些相互作用的功能的已知信息。
