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鉴定产类毒素-a的颤藻属蓝细菌特有的聚酮合酶编码序列。

Identification of a polyketide synthase coding sequence specific for anatoxin-a-producing Oscillatoria cyanobacteria.

作者信息

Cadel-Six Sabrina, Iteman Isabelle, Peyraud-Thomas Caroline, Mann Stéphane, Ploux Olivier, Méjean Annick

机构信息

Unité des Cyanobactéries (URA CNRS 2172), Institut Pasteur, 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France.

出版信息

Appl Environ Microbiol. 2009 Jul;75(14):4909-12. doi: 10.1128/AEM.02478-08. Epub 2009 May 15.

DOI:10.1128/AEM.02478-08
PMID:19447947
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2708435/
Abstract

We report the identification of a sequence from the genome of Oscillatoria sp. strain PCC 6506 coding for a polyketide synthase. Using 50 axenic cyanobacteria, we found this sequence only in the genomes of Oscillatoria strains producing anatoxin-a or homoanatoxin-a, indicating its likely involvement in the biosynthesis of these toxins.

摘要

我们报告了从颤藻属（Oscillatoria sp.）菌株PCC 6506基因组中鉴定出一段编码聚酮合酶的序列。利用50种无菌蓝细菌，我们发现该序列仅存在于产生anatoxin-a或homoanatoxin-a的颤藻菌株基因组中，这表明它可能参与了这些毒素的生物合成。

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Curr Opin Biotechnol. 2008 Jun;19(3):281-8. doi: 10.1016/j.copbio.2008.03.002. Epub 2008 Apr 23.
2
Characterization of the gene cluster responsible for cylindrospermopsin biosynthesis.负责柱孢藻毒素生物合成的基因簇的表征
Appl Environ Microbiol. 2008 Feb;74(3):716-22. doi: 10.1128/AEM.01988-07. Epub 2007 Dec 7.
3
Different genotypes of anatoxin-producing cyanobacteria coexist in the Tarn River, France.在法国的塔恩河中，产anatoxin的蓝藻细菌的不同基因型共存。
Appl Environ Microbiol. 2007 Dec;73(23):7605-14. doi: 10.1128/AEM.01225-07. Epub 2007 Oct 12.
4
Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics.聚酮合酶和非核糖体肽合成酶：细菌基因组学的新观点
Nat Prod Rep. 2007 Oct;24(5):1073-109. doi: 10.1039/b514050c. Epub 2007 May 10.
5
First report of homoanatoxin-a and associated dog neurotoxicosis in New Zealand.新西兰首例人型anatoxin-a及相关犬类神经中毒报告。
Toxicon. 2007 Aug;50(2):292-301. doi: 10.1016/j.toxicon.2007.03.025. Epub 2007 Apr 13.
6
Toxins of cyanobacteria.蓝藻毒素
Mol Nutr Food Res. 2007 Jan;51(1):7-60. doi: 10.1002/mnfr.200600185.
7
First report in a river in France of the benthic cyanobacterium Phormidium favosum producing anatoxin-a associated with dog neurotoxicosis.法国一条河流中首次报告底栖蓝藻席藻产生与犬神经中毒相关的anatoxin-a 。
Toxicon. 2005 Jun 1;45(7):919-28. doi: 10.1016/j.toxicon.2005.02.031. Epub 2005 Apr 13.
8
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9
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10
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J Mol Evol. 2003 Apr;56(4):446-57. doi: 10.1007/s00239-002-2415-0.