突变积累、软选择与中产阶级社区。
Mutation accumulation, soft selection and the middle-class neighborhood.
机构信息
Department of Genetics, University of Georgia, Athens, Georgia 30602-7223, USA.
出版信息
Genetics. 2009 Aug;182(4):1387-9. doi: 10.1534/genetics.109.101436. Epub 2009 May 17.
Abstract
The "middle-class neighborhood" is a breeding design intended to allow new mutations to accumulate by lessening the effects of purifying selection through the elimination of among-line fitness variation. We show that this design effectively applies soft selection to the experimental population, potentially causing biased estimates of mutational effects if social effects contribute to fitness.
摘要
“中产阶级社区”是一种培育设计，旨在通过消除谱系内适应度变异来减少净化选择的影响，从而允许新的突变积累。我们表明，这种设计有效地对实验种群施加了软选择，如果社会效应有助于适应度，那么可能会导致对突变效应的有偏差估计。
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