秀丽隐杆线虫生活史性状的自发突变率。
The rate of spontaneous mutation for life-history traits in Caenorhabditis elegans.
作者信息
Vassilieva L L, Lynch M
机构信息
Department of Biology, University of Oregon, Eugene, Oregon 97403,
出版信息
Genetics. 1999 Jan;151(1):119-29. doi: 10.1093/genetics/151.1.119.
Abstract
Spontaneous mutations were accumulated in 100 replicate lines of Caenorhabditis elegans over a period of approximately 50 generations. Periodic assays of these lines and comparison to a frozen control suggest that the deleterious mutation rate for typical life-history characters in this species is at least 0.05 per diploid genome per generation, with the average mutational effect on the order of 14% or less in the homozygous state and the average mutational heritability approximately 0.0034. While the average mutation rate per character and the average mutational heritability for this species are somewhat lower than previous estimates for Drosophila, these differences can be reconciled to a large extent when the biological differences between these species are taken into consideration.
摘要
在大约50代的时间里，100个秀丽隐杆线虫的重复品系积累了自发突变。对这些品系的定期检测以及与冷冻对照的比较表明，该物种典型生活史特征的有害突变率至少为每代每个二倍体基因组0.05，纯合状态下平均突变效应约为14%或更低，平均突变遗传力约为0.0034。虽然该物种每个性状的平均突变率和平均突变遗传力略低于先前对果蝇的估计，但当考虑到这些物种之间的生物学差异时，这些差异在很大程度上是可以调和的。
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