Naĭkhin A N, Artem'eva S A, Ermachenko T A, Vybornykh E N, Kustikova Iu G, Doroshenko E V, Katorgina L G, Denisov G M, Kim T N
Vopr Virusol. 1993 Sep-Dec;38(5):204-7.
The functional activity of serum antibody had been shown previously to reflect the state of resistance to influenza more accurately than antibody concentration. The functional activity of antibodies in the vaccination process was studied. The immune response to influenza antigens was found to be accompanied by an increase in the functional activity of antibodies, the intensity of this increase was the highest in natural influenza infection, moderate after administration of live vaccines and the least after immunization with inactivated preparations. The vaccine strains may differ significantly in their capacity to stimulate antibody with high functional activity. The quantitative parameters of the functional activity of antibody are directly related to the antigen dose and frequency of antigenic stimulation.
血清抗体的功能活性此前已被证明比抗体浓度更能准确反映对流感的抵抗状态。研究了疫苗接种过程中抗体的功能活性。发现对流感抗原的免疫反应伴随着抗体功能活性的增加，这种增加的强度在自然流感感染中最高，接种活疫苗后适中，用灭活制剂免疫后最低。疫苗毒株在刺激具有高功能活性抗体的能力上可能有显著差异。抗体功能活性的定量参数与抗原剂量和抗原刺激频率直接相关。
