Gusatti Carolina de Souza, Ferreira Alessandra Einsfeld, Fuentefria Daiane Bopp, Corção Gertrudes
Departamento de Microbiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS.
Rev Soc Bras Med Trop. 2009 Mar-Apr;42(2):183-7. doi: 10.1590/s0037-86822009000200018.
Acinetobacter spp is an important pathogen that is responsible for nosocomial infections affecting immunocompromised patients, and it can easily acquire resistance to antimicrobial agents. Hospital sewage is an important means for disseminating genes for resistance to antimicrobial agents, to the microbiota of the environment. Within this context, 30 strains of Acinetobacter spp from the sewage of a hospital in Porto Alegre, Rio Grande do Sul, were analyzed regarding their profile of susceptibility to beta-lactams, quinolones and aminoglycosides, by means of an antibiogram and tests to screen for metallo-beta-lactamases and extended-spectrum beta-lactamases. The profile obtained revealed the presence of multidrug-resistant strains and showed that resistance mechanisms such as the production of extended-spectrum beta-lactamases and efflux pumps may be present in these strains.
不动杆菌属是一种重要的病原体,可导致医院感染,影响免疫功能低下的患者,并且它很容易获得对抗菌药物的耐药性。医院污水是抗菌药物耐药基因向环境微生物群传播的重要途径。在此背景下,通过抗菌谱分析以及金属β-内酰胺酶和超广谱β-内酰胺酶的筛选试验,对巴西南部阿雷格里港一家医院污水中的30株不动杆菌属菌株进行了β-内酰胺类、喹诺酮类和氨基糖苷类药物敏感性分析。所得结果显示存在多重耐药菌株,并表明这些菌株可能存在超广谱β-内酰胺酶产生和外排泵等耐药机制。