Guardabassi L, Petersen A, Olsen J E, Dalsgaard A
Department of Veterinary Microbiology, The Royal Veterinary and Agricultural University, 1870 Frederiksberg C., Denmark.
Appl Environ Microbiol. 1998 Sep;64(9):3499-502. doi: 10.1128/AEM.64.9.3499-3502.1998.
The possible increase of antibiotic-resistant bacteria in sewage associated with the discharge of wastewater from a hospital and a pharmaceutical plant was investigated by using Acinetobacter species as environmental bacterial indicators. The level of susceptibility to six antimicrobial agents was determined in 385 Acinetobacter strains isolated from samples collected upstream and downstream from the discharge points of the hospital and the pharmaceutical plant. Results indicated that while the hospital waste effluent affected only the prevalence of oxytetracycline resistance, the discharge of wastewater from the pharmaceutical plant was associated with an increase in the prevalence of both single- and multiple-antibiotic resistance among Acinetobacter species in the sewers.
通过使用不动杆菌属作为环境细菌指标，研究了与医院和制药厂废水排放相关的污水中抗生素抗性细菌可能增加的情况。对从医院和制药厂排放点上游和下游采集的样本中分离出的385株不动杆菌菌株，测定了其对六种抗菌剂的敏感性水平。结果表明，虽然医院废水仅影响土霉素抗性的流行率，但制药厂废水的排放与下水道中不动杆菌属单一和多重抗生素抗性的流行率增加有关。
