Yoshimasu F, Kokmen E, Hay I D, Beard C M, Offord K P, Kurland L T
Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905.
Neurology. 1991 Nov;41(11):1745-7. doi: 10.1212/wnl.41.11.1745.
To determine whether an association exists between Alzheimer's disease (AD) and thyroid disease, we carried out two studies in the population of Rochester, Minnesota. We reviewed medical records of a cohort of 198 women with histologically confirmed Hashimoto's thyroiditis (1935 to 1974) for evidence of subsequent dementia, applying the criteria used for dementia in a previous determination of incidence and prevalence rates in this population. From a total of 4,197 person-years of follow-up, eight cases of AD were diagnosed, whereas the expected number was 5.8. The standardized morbidity ratio was 1.37, which failed to reach statistical significance. The second study was a retrospective case-control comparison that sought any relationship between AD and all thyroid disorders, using a previously identified (1960 to 1979) AD cohort (N = 646) and their age- and sex-matched controls. For myxedema there was a positive association for AD without significance, whereas in Graves' disease there was a significant negative association for AD.
为了确定阿尔茨海默病（AD）与甲状腺疾病之间是否存在关联，我们在明尼苏达州罗切斯特市的人群中开展了两项研究。我们查阅了一组198名经组织学确诊为桥本甲状腺炎的女性（1935年至1974年）的病历，以寻找后续痴呆症的证据，采用了该人群先前发病率和患病率测定中用于痴呆症的标准。在总共4197人年的随访中，诊断出8例AD病例，而预期数量为5.8例。标准化发病比为1.37，未达到统计学显著性。第二项研究是一项回顾性病例对照比较，使用先前确定的（1960年至1979年）AD队列（N = 646）及其年龄和性别匹配的对照，寻找AD与所有甲状腺疾病之间的任何关系。对于黏液性水肿，AD存在正相关但无显著性，而在格雷夫斯病中，AD存在显著负相关。
