Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos. 6627, Belo Horizonte, Minas Gerais, CEP 31270-901, Brazil.
J Thromb Thrombolysis. 2010 Apr;29(3):276-81. doi: 10.1007/s11239-009-0345-z. Epub 2009 May 17.
This study investigated the correlation of sPLA2 (secretory phospholipase A2) activity with the atheromatosis extent in subjects with coronary artery disease (CAD) undergoing coronary angiography. We analyzed 123 patients, including 35 subjects with angiographically normal coronary arteries (controls), 31 with mild/moderate atheromatosis (stenosis of 30-70% of the luminal diameter in one or more coronary arteries) and 57 with severe atheromatosis (>70% stenosis). Plasma sPLA2 activity was significantly higher in subjects with severe [127.7 U/ml (102.3-162.7); p < 0.0001] and mild/moderate [112.0 U/ml (100.6-146.9); p < 0.0001] atheromatosis than in controls [19.8 U/ml (15.1-32.1)]. In a multiple logistic regression model, adjusted for age, gender, body mass index, tabagism, hypertension, sedentarism, family history for coronary artery disease, diabetes mellitus, total cholesterol, HDLc, LDLc, triglycerides, high sensitivity C-reactive protein and phospholipase A2, only sPLA2 was observed to be independently associated with severe CAD (>70% of stenosis) (p < 0.0001).
本研究旨在探讨在接受冠状动脉造影的冠心病（CAD）患者中，分泌型 PLA2（sPLA2）活性与动脉粥样硬化程度的相关性。我们分析了 123 名患者，包括 35 名冠状动脉造影正常的患者（对照组）、31 名轻度/中度动脉粥样硬化患者（一条或多条冠状动脉管腔狭窄 30-70%）和 57 名严重动脉粥样硬化患者（狭窄>70%）。严重动脉粥样硬化患者的血浆 sPLA2 活性显著升高[127.7 U/ml（102.3-162.7）；p<0.0001]和轻度/中度动脉粥样硬化患者[112.0 U/ml（100.6-146.9）；p<0.0001]，明显高于对照组[19.8 U/ml（15.1-32.1）]。在经年龄、性别、体重指数、吸烟、高血压、静坐生活方式、冠心病家族史、糖尿病、总胆固醇、HDLc、LDLc、甘油三酯、高敏 C 反应蛋白和 PLA2 调整的多因素逻辑回归模型中，仅 sPLA2 与严重 CAD（>70%狭窄）独立相关（p<0.0001）。
