Litvinas Nichole D, Brodsky Benjamin H, Du Bois J
Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA.
Angew Chem Int Ed Engl. 2009;48(25):4513-6. doi: 10.1002/anie.200901353.
Substituted benzoxathiazines function as catalysts for the selective hydroxylation of tertiary C-H bonds. Mechanistic studies have revealed an unanticipated disparity between oxaziridine reactivity and catalyst performance and have given way to a new catalyst and an aqueous H(2)O(2) reaction protocol that greatly facilitate such transformations (see scheme).
