Yoshida A, Feke G T, Ogasawara H, Goger D G, Murray D L, McMeel J W
Department of Ophthalmology, Asahikawa Medical College, Japan.
Ophthalmic Res. 1991;23(3):162-70. doi: 10.1159/000267116.
In a double-masked, randomized, placebo-controlled study, we evaluated the effect of topical timolol maleate 0.5% on the retinal, choroidal, and optic nerve head circulation in 5 healthy volunteer subjects. Changes in the pulsatile component of choroidal blood flow (PCBF) were determined from measurements of the ocular pulse wave. Changes in the retinal arterial blood flow rate (RBF) and optic nerve head capillary blood speed (CBS) were determined by laser Doppler velocimetry and monochromatic photography. In timolol-treated eyes, PCBF decreased by 32 +/- 12% (p = 0.0007). Changes in RBF and CBS were not statistically significant. In the contralateral placebo-treated eyes, PCBF decreased by 15 +/- 8% (p = 0.006) and RBF increased by 18 +/- 10% (p = 0.002). The change in CBS was not statistically significant.
在一项双盲、随机、安慰剂对照研究中，我们评估了0.5%的局部马来酸噻吗洛尔对5名健康志愿者视网膜、脉络膜和视神经乳头循环的影响。脉络膜血流的搏动成分（PCBF）变化通过眼脉搏波测量来确定。视网膜动脉血流速率（RBF）和视神经乳头毛细血管血流速度（CBS）的变化通过激光多普勒测速法和单色摄影来确定。在使用噻吗洛尔治疗的眼睛中，PCBF下降了32±12%（p = 0.0007）。RBF和CBS的变化无统计学意义。在对侧使用安慰剂治疗的眼睛中，PCBF下降了15±8%（p = 0.006），RBF增加了18±10%（p = 0.002）。CBS的变化无统计学意义。
