来自蚧虫真菌细薄托盘菌BCC 12732的异香豆素糖苷。
Isocoumarin glucosides from the scale insect fungus Torrubiella tenuis BCC 12732.
作者信息
Kornsakulkarn Jittra, Thongpanchang Chawanee, Lapanun Sanisa, Srichomthong Kitlada
机构信息
National Center for Genetic Engineering and Biotechnology, Klong Luang, Pathumthani 12120, Thailand.
出版信息
J Nat Prod. 2009 Jul;72(7):1341-3. doi: 10.1021/np900082h.
Three new isocoumarin glucosides (1, 3, and 4), 6,8-dihydroxy-3-methylisocoumarin (2), and 6,8-dihydroxy-3-hydroxymethylisocoumarin (5) were isolated from the scale insect pathogenic fungus Torrubiella tenuis BCC 12732. Structures of these compounds were elucidated using NMR spectroscopic and MS spectrometric analyses. Compound 5 exhibited moderate anti-HSV-1 and antimycobacterial activities with IC(50) and MIC values of 50 and 25 microg/mL, respectively.
从蚧虫病原真菌细薄座束梗孢菌Torrubiella tenuis BCC 12732中分离出三种新的异香豆素糖苷（1、3和4）、6,8-二羟基-3-甲基异香豆素（2）和6,8-二羟基-3-羟甲基异香豆素（5）。通过核磁共振光谱分析和质谱分析确定了这些化合物的结构。化合物5表现出中等程度的抗单纯疱疹病毒1型（HSV-1）和抗分枝杆菌活性，其半数抑制浓度（IC50）和最低抑菌浓度（MIC）值分别为50和25微克/毫升。
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