多发性硬化症患者的出汗功能障碍
Sweating impairment in patients with multiple sclerosis.
作者信息
Saari A, Tolonen U, Pääkkö E, Suominen K, Jauhiainen J, Sotaniemi K A, Myllylä V V
机构信息
Department of Neurology, Oulu University Hospital, Oulu, Finland.
出版信息
Acta Neurol Scand. 2009 Nov;120(5):358-63. doi: 10.1111/j.1600-0404.2009.01164.x. Epub 2009 May 19.
OBJECTIVES
To measure sweating in patients with multiple sclerosis (MS).
MATERIALS AND METHODS
Sweating was measured by an evaporimeter after a heating stimulus in 29 MS patients and in 15 healthy control subjects.
RESULTS
The MS patients sweated markedly less than the controls. After 10 min of heating the sweating was significantly lower in the forehead (P = 0.034), feet (right, P = 0.033; left, P = 0.037) and legs (right, P = 0.043; left, P = 0.029) of the MS patients than in those of the controls. After 15 min of heating the difference was statistically significant only in the feet (right, P = 0.043; left, P = 0.029). The Expanded Disability Status Scale score correlated inversely with sweating at 15 min of heating in the left hand (r = 0.42, P < 0.05), and in the left (r = 0.36, P < 0.05) and right foot (r = 0.37, P < 0.05).
CONCLUSIONS
MS is associated with an impairment in thermoregulatory sweating which seems to be related to the disease severity.
目的
测量多发性硬化症（MS）患者的出汗情况。
材料与方法
对29例MS患者和15名健康对照者在热刺激后用蒸发仪测量出汗情况。
结果
MS患者出汗明显少于对照组。加热10分钟后，MS患者前额（P = 0.034）、足部（右侧，P = 0.033；左侧，P = 0.037）和腿部（右侧，P = 0.043；左侧，P = 0.029）的出汗量明显低于对照组。加热15分钟后，差异仅在足部有统计学意义（右侧，P = 0.043；左侧，P = 0.029）。扩展残疾状态量表评分与加热15分钟时左手（r = 0.42，P < 0.05）、左脚（r = 0.36，P < 0.05）和右脚（r = 0.37，P < 0.05）的出汗量呈负相关。
结论
MS与体温调节性出汗受损有关，这似乎与疾病严重程度相关。
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