Huang Mu, Jay Ollie, Davis Scott L
Department of Applied Physiology & Wellness, Southern Methodist University, Dallas, TX, United States.
Faculty of Health Sciences, University of Sydney, Sydney, Australia.
Auton Neurosci. 2015 Mar;188:82-5. doi: 10.1016/j.autneu.2014.10.017. Epub 2014 Oct 23.
Multiple sclerosis (MS), a progressive neurological disease, can result in autonomic dysfunction. Impairments in the autonomic control of cardiovascular and thermoregulatory function during exercise have been observed in MS. Attenuated elevations in blood pressure during exercise in MS patients can negatively impact blood flow to skeletal muscle. Diminished sweating during exercise may impair heat dissipation likely limiting the exercise intensity that can be performed before detrimental core temperatures are reached. Further understanding the physiologic mechanisms of autonomic dysfunction during exercise in MS may lead to the development of novel therapeutic strategies targeted at improving quality of life in individuals with this disease.
多发性硬化症（MS）是一种进行性神经疾病，可导致自主神经功能障碍。在MS患者中，已观察到运动期间心血管和体温调节功能的自主神经控制受损。MS患者运动期间血压升高减弱可能会对骨骼肌的血流产生负面影响。运动期间出汗减少可能会损害散热，可能会限制在达到有害的核心体温之前能够进行的运动强度。进一步了解MS患者运动期间自主神经功能障碍的生理机制，可能会导致开发针对改善该疾病患者生活质量的新型治疗策略。
