多发性硬化症患者对热的敏感性：强烈影响症状学的因素——一项探索性调查。
Sensitivity to heat in MS patients: a factor strongly influencing symptomology--an explorative survey.
机构信息
Department of Medicine and Health, Division of Nursing Science, Faculty of Health Sciences, Linköping University, SE-581 85 Linköping, Sweden.
出版信息
BMC Neurol. 2011 Feb 25;11:27. doi: 10.1186/1471-2377-11-27.
BACKGROUND
Many individuals diagnosed with Multiple Sclerosis (MS) are sensitive to increased body temperature, which has been recognized as correlating with the symptom of fatigue. The need to explore this association has been highlighted. The aim of this study was to investigate the occurrence of heat sensitivity and its relations to disease course, disability, common MS-related symptoms and ongoing immunosuppressive treatments among individuals 65 years of age or younger diagnosed with MS.
METHODS
A cross-sectional designed survey was undertaken. A questionnaire was sent to MS-patients with an Expanded Disability Status Score (EDSS) in the interval of 0-6.5 and who were between 20 and 65 years of age, living in an eastern region of Sweden (n = 334). Besides occurrence of heat sensitivity (Yes/No) and corresponding questions, the Fatigue Severity Scale (FSS), the MS-related symptom checklist and the Perceived Deficit Questionnaire (PDQ) were included. Data were analysed in relation to data level using Chi-square, Mann Whitney U-test, and Student's t-test. Pearson's and Spearman's correlations were calculated. In the logistic regression analyses (enter) dichotomized MS-symptoms were used as dependent variables, and EDSS, disease-course, time since onset, heat-sensitivity, age and sex (female/male) were independent variables. In the linear regression analyses, enter, mean FSS and summarized PDQ were entered as dependent variables and EDSS, disease-course, time since onset, heat sensitivity, age and sex (female/male) were independent variables.
RESULTS
Of the responding patients (n = 256), 58% reported heat sensitivity. The regression analyses revealed heat sensitivity as a significant factor relating not only to fatigue (p < 0.001), but also to several other common MS symptoms such as pain (p < 0.001), concentration difficulties (p < 0.001), and urination urgency (p = 0.009).
CONCLUSIONS
Heat sensitivity in MS patients is a key symptom that is highly correlated with disabling symptoms such as fatigue, pain, concentration difficulty and urination urgency.
背景
许多多发性硬化症（MS）患者对体温升高敏感，这已被认为与疲劳症状有关。因此，需要探索这种关联。本研究的目的是调查 65 岁以下被诊断为 MS 的个体中热敏感性的发生情况及其与疾病过程、残疾、常见 MS 相关症状和正在进行的免疫抑制治疗的关系。
方法
采用横断面设计调查。向处于 0-6.5 之间的扩展残疾状态评分（EDSS）的年龄在 20-65 岁之间的 MS 患者发送问卷，并居住在瑞典东部地区（n=334）。除了发生热敏感性（是/否）和相应的问题外，还包括疲劳严重程度量表（FSS）、MS 相关症状清单和感知缺陷问卷（PDQ）。使用卡方检验、Mann Whitney U 检验和学生 t 检验分析与数据水平相关的数据。计算 Pearson 和 Spearman 相关性。在逻辑回归分析（进入）中，将二分类 MS 症状作为因变量，EDSS、疾病过程、发病时间、热敏感性、年龄和性别（女性/男性）作为自变量。在线性回归分析中，进入、平均 FSS 和总结 PDQ 作为因变量，EDSS、疾病过程、发病时间、热敏感性、年龄和性别（女性/男性）作为自变量。
结果
在回复的患者中（n=256），58%报告有热敏感性。回归分析显示，热敏感性不仅与疲劳显著相关（p<0.001），还与其他常见 MS 症状如疼痛（p<0.001）、注意力集中困难（p<0.001）和尿急（p=0.009）显著相关。
结论
MS 患者的热敏感性是一种关键症状，与疲劳、疼痛、注意力集中困难和尿急等致残症状高度相关。
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