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Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130150. doi: 10.1098/rstb.2013.0150. Print 2014 Jan 5.
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Deciphering the molecular rules governing synaptic targeting of the memory-related protein Arc.破解调控记忆相关蛋白Arc突触定位的分子规则。
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Creb1-Mecp2-(m)CpG complex transactivates postnatal murine neuronal glucose transporter isoform 3 expression.Creb1-Mecp2-(m)CpG 复合物反式激活出生后小鼠神经元葡萄糖转运体 3 表达。
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Synaptic activity-responsive element (SARE): A unique genomic structure with an unusual sensitivity to neuronal activity.突触活动反应元件（SARE）：一种对神经元活动具有异常敏感性的独特基因组结构。
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本文引用的文献

1
TORC1 regulates activity-dependent CREB-target gene transcription and dendritic growth of developing cortical neurons.TORC1调节发育中皮质神经元的活性依赖型CREB靶基因转录和树突生长。
J Neurosci. 2009 Feb 25;29(8):2334-43. doi: 10.1523/JNEUROSCI.2296-08.2009.
2
The CREB/CREM transcription factors negatively regulate early synaptogenesis and spontaneous network activity.CREB/CREM转录因子对早期突触形成和自发网络活动起负向调节作用。
J Neurosci. 2009 Jan 14;29(2):328-33. doi: 10.1523/JNEUROSCI.5252-08.2009.
3
Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons.Arc/Arg3.1启动子中对激活神经元的突触到细胞核信号传导至关重要的突触活动反应元件。
Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):316-21. doi: 10.1073/pnas.0806518106. Epub 2008 Dec 30.
4
Generation of silent synapses by acute in vivo expression of CaMKIV and CREB.通过体内急性表达CaMKIV和CREB产生沉默突触。
Neuron. 2005 Mar 3;45(5):741-52. doi: 10.1016/j.neuron.2005.01.039.
5
Disruption of CREB function in brain leads to neurodegeneration.大脑中CREB功能的破坏会导致神经退行性变。
Nat Genet. 2002 May;31(1):47-54. doi: 10.1038/ng882. Epub 2002 Apr 22.
6
CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals.CREB：一种由多种细胞外信号激活的刺激诱导转录因子。
Annu Rev Biochem. 1999;68:821-61. doi: 10.1146/annurev.biochem.68.1.821.
7
A developmental change in NMDA receptor-associated proteins at hippocampal synapses.海马突触中NMDA受体相关蛋白的发育变化。
J Neurosci. 2000 Feb 1;20(3):1260-71. doi: 10.1523/JNEUROSCI.20-03-01260.2000.
8
Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons.CREB家族转录因子介导的神经生长因子依赖的交感神经元存活。
Science. 1999 Dec 17;286(5448):2358-61. doi: 10.1126/science.286.5448.2358.
9
The establishment of GABAergic and glutamatergic synapses on CA1 pyramidal neurons is sequential and correlates with the development of the apical dendrite.γ-氨基丁酸能和谷氨酸能突触在CA1锥体神经元上的建立是相继发生的，且与顶端树突的发育相关。
J Neurosci. 1999 Dec 1;19(23):10372-82. doi: 10.1523/JNEUROSCI.19-23-10372.1999.
10
Altered emotional and locomotor responses in mice deficient in the transcription factor CREM.转录因子CREM缺陷小鼠的情绪和运动反应改变。
Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14094-9. doi: 10.1073/pnas.96.24.14094.

A Janus-like role of CREB protein: enhancement of synaptic property in mature neurons and suppression of synaptogenesis and reduced network synchrony in early development.

作者信息

Nonaka Mio

机构信息

Department of Neurochemistry, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

出版信息

J Neurosci. 2009 May 20;29(20):6389-91. doi: 10.1523/JNEUROSCI.1309-09.2009.

DOI:10.1523/JNEUROSCI.1309-09.2009
PMID:19458209
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6665887/
Abstract
摘要