急性早幼粒细胞白血病（APL）中的出血：纤溶还是去纤维蛋白？

Bleeding in acute promyelocytic leukemia (APL): fibrinolysis or defibrination?

作者信息

Krsnik I, Escribá A, López-Rubio M, Alarcón C, del Potro E, Díaz-Mediavilla J

机构信息

Servicio de Hematología, Hospital Clínico de San Carlos, Madrid, Espagne.

出版信息

Nouv Rev Fr Hematol (1978). 1991;33(1):39-41.

PMID:1945823

Abstract

The coagulation abnormalities in 20 cases of acute promyelocytic leukemia (APL) treated at a single institution were reviewed. A remarkably uniform picture of defibrination and increased FDPs with well-preserved levels of other coagulation factors including AT-III was seen. Our data, together with those available in the literature, do not support DIC as the underlying mechanism of bleeding but seem rather to point to increased proteolysis as the cause.

摘要

回顾了在单一机构接受治疗的20例急性早幼粒细胞白血病（APL）患者的凝血异常情况。观察到显著一致的纤维蛋白溶解和FDPs增加的情况，而包括抗凝血酶III（AT-III）在内的其他凝血因子水平保持良好。我们的数据以及文献中可得的数据均不支持弥散性血管内凝血（DIC）作为出血的潜在机制，而是似乎指向蛋白水解增加作为病因。