潜伏性胶原酶是酶-抑制剂复合物的证据。
Evidence that latent collagenases are enzyme-inhibitor complexes.
作者信息
Sellers A, Cartwright E, Murphy G, Reynolds J J
出版信息
Biochem J. 1977 May 1;163(2):303-7. doi: 10.1042/bj1630303.
Abstract
Specific collagenase from the culture media of various rabbit tissues and cells exists in active and latent forms. Latent collagenase is most effectively activated with 4-aminophenylmercuric acetate, a thiol-blocking reagent, strongly suggesting that latent forms are enzyme-inhibitor complexes. A collagenase inhibitor from bone cultures, which may be closely related to the inhibitor of such latent enzyme complexes, was partially characterized.
摘要
来自各种兔组织和细胞培养基的特异性胶原酶以活性和潜伏形式存在。潜伏性胶原酶最有效地被硫醇阻断剂乙酸4-氨基苯汞激活，这强烈表明潜伏形式是酶-抑制剂复合物。对来自骨培养物的一种胶原酶抑制剂进行了部分特性分析，该抑制剂可能与这种潜伏酶复合物的抑制剂密切相关。
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