Mohamad Ragaa Hosny, Zekry Zekry Khalid, Al-Mehdar Hussain A, Salama Omar, El-Shaieb Siad Ebrahim, El-Basmy Amany A, Al-said Mohamad Gamil Abdel Monem, Sharawy Sabry Mohamed
Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
J Med Food. 2009 Apr;12(2):461-5. doi: 10.1089/jmf.2008.0009.
There is a traditional belief in the Middle East that regular consumption of camel milk may aid in prevention and control of diabetes. The aim of this work was to evaluate the efficacy of camel milk as an adjuvant therapy in young type 1 diabetics. This 16-week randomized study enrolled 54 type 1 diabetic patients (average age 20 years) selected from those attending the outpatient diabetes clinic of the Menofia University Hospital, affiliated with Egypt's National Cancer Institute. Subjects were randomly divided into two groups of 27 patients: one received usual management (diet, exercise, and insulin), whereas the other received 500 mL of camel milk daily in addition to standard management. A control group of 10 healthy subjects was also assessed. The following parameters were evaluated at baseline and at 4 and 16 weeks: hemoglobin A1c (HbA1c), human C-peptide, lipid profile, serum insulin, anti-insulin antibodies, creatinine clearance, albumin in 24-hour urine, body mass index, and Diabetes Quality of Life score. The following parameters were significantly different between the usual-management group versus the camel milk group after 16 weeks: fasting blood sugar (227.2 +/- 17.7 vs. 98.9 +/- 16.2 mg/dL), HbA1c (9.59 +/- 2.05[%] vs. 7.16 +/- 1.84[%]), serum anti-insulin antibodies (26.20 +/- 7.69 vs. 20.92 +/- 5.45 microU/mL), urinary albumin excretion (25.17 +/- 5.43 vs. 14.54 +/- 5.62 mg/dL/24 hours), daily insulin dose (48.1 +/- 6.95 vs. 23 +/- 4.05 units), and body mass index (18.43 +/- 3.59 vs. 24.3 +/- 2.95 kg/m(2)). Most notably, C-peptide levels were markedly higher in the camel milk group (0.28 +/- 0.6 vs. 2.30 +/- 0.51 pmol/mL). These results suggest that, as an adjunct to standard management, daily ingestion of camel milk can aid metabolic control in young type 1 diabetics, at least in part by boosting endogenous insulin secretion.
中东地区有一种传统观念，认为经常饮用骆驼奶可能有助于预防和控制糖尿病。这项研究的目的是评估骆驼奶作为年轻1型糖尿病患者辅助治疗手段的疗效。这项为期16周的随机研究招募了54名1型糖尿病患者（平均年龄20岁），这些患者选自隶属于埃及国家癌症研究所的米尼亚大学医院门诊糖尿病诊所的就诊者。受试者被随机分为两组，每组27名患者：一组接受常规治疗（饮食、运动和胰岛素），而另一组除标准治疗外，每天还饮用500毫升骆驼奶。还评估了一个由10名健康受试者组成的对照组。在基线、4周和16周时评估了以下参数：糖化血红蛋白（HbA1c）、人C肽、血脂谱、血清胰岛素、抗胰岛素抗体、肌酐清除率、24小时尿白蛋白、体重指数和糖尿病生活质量评分。16周后，常规治疗组与骆驼奶组之间的以下参数存在显著差异：空腹血糖（227.2±17.7对98.9±16.2毫克/分升）、HbA1c（9.59±2.05[%]对7.16±1.84[%]）、血清抗胰岛素抗体（26.20±7.69对20.92±5.45微单位/毫升）、尿白蛋白排泄量（25.17±5.43对14.54±5.62毫克/分升/24小时）、每日胰岛素剂量（48.1±6.95对23±4.05单位）和体重指数（18.43±3.59对24.3±2.95千克/米²）。最值得注意的是，骆驼奶组的C肽水平明显更高（0.28±0.6对2.30±0.51皮摩尔/毫升）。这些结果表明，作为标准治疗的辅助手段，每天饮用骆驼奶可以帮助年轻1型糖尿病患者进行代谢控制，至少部分是通过促进内源性胰岛素分泌来实现的。
