Zampetti Anna, Rigante Donato, Bersani Giulia, Rendeli Claudia, Feliciani Claudio, Stabile Achille
Department of Dermatology, Università Cattolica Sacro Cuore, 00168 Rome, Italy.
Clin Rheumatol. 2009 Sep;28(9):1101-5. doi: 10.1007/s10067-009-1200-5. Epub 2009 May 22.
The aim of this study is to describe by video-nailfold capillaroscopy the microvascular involvement and capillary changes in children with Henoch-Schönlein purpura (HSp) and to establish a possible correlation with clinical outcome. Thirty-one patients underwent capillaroscopic evaluation through a videomicroscope during the acute phase and after 6 months. Twenty sex/age-matched controls were also examined. All capillaroscopic variables were statistically examined in combination with laboratoristic/clinical data. Architectural and morphological changes recorded during the acute phase were statistically significant in comparison to the controls (p < 0.01). At the follow-up, oedema was still observed in all patients, whereas, morphological changes only in two. There was a no significant correlation between capillaroscopy changes, laboratoristic/clinical data, and outcome. Video-nailfold capillaroscopy can be a simple tool to evaluate microvascular abnormalities in the acute phase of HSp, and the persistence of oedema could suggest an incomplete disease resolution at a microvascular level.
本研究的目的是通过视频甲襞毛细血管镜描述过敏性紫癜（HSp）患儿的微血管受累情况及毛细血管变化，并建立其与临床结局之间的可能关联。31例患者在急性期和6个月后通过视频显微镜进行了毛细血管镜评估。还检查了20名性别/年龄匹配的对照者。所有毛细血管镜变量均与实验室/临床数据相结合进行统计学检验。急性期记录的结构和形态学变化与对照组相比具有统计学意义（p < 0.01）。随访时，所有患者仍观察到水肿，而形态学变化仅在2例中出现。毛细血管镜检查变化、实验室/临床数据与结局之间无显著相关性。视频甲襞毛细血管镜可作为评估HSp急性期微血管异常的一种简单工具，水肿的持续存在可能提示在微血管水平上疾病未完全缓解。
