中性α-葡萄糖苷酶活性在男科学中的相关性。

The relevance of neutral alpha-glucosidase activity in andrology.

作者信息

Levrant Seth, Watanabe Marisela, Land Spencer, Sauer Ruben, Jeyendran Rajasingam S

机构信息

Partners in Reproductive Health, Tinley Park, IL, USA.

出版信息

Syst Biol Reprod Med. 2009 Mar-Apr;55(2):116-9. doi: 10.1080/19396360902801935.

DOI:10.1080/19396360902801935

PMID:19462291

Abstract

To assess the usefulness of routine determination of neutral alpha-glucosidase (NAG) in andrology, 216 ejaculates were analyzed for NAG activity and semen quality. A correlation between NAG activity and semen volume and sperm concentration was determined; however, no correlation was observed between NAG activity and sperm motility or sperm morphology. The number of azoospermic ejaculates that had NAG activity below acceptable levels was significantly higher than the number of non-azoospermic ejaculates with similarly low NAG levels. Routine determination of NAG activity is not practical; however, when an epididymal pathology leading to a physiological or anatomical functional alteration is suspected, the determination of NAG activity is a valuable tool in the diagnosis, and would also aid in the prognosis.

摘要

为评估常规检测中性α-葡萄糖苷酶（NAG）在男科学中的作用，对216份精液样本进行了NAG活性和精液质量分析。确定了NAG活性与精液量和精子浓度之间的相关性；然而，未观察到NAG活性与精子活力或精子形态之间存在相关性。NAG活性低于可接受水平的无精子症精液样本数量显著高于NAG水平同样较低的非无精子症精液样本数量。常规检测NAG活性并不实用；然而，当怀疑存在导致生理或解剖功能改变的附睾病理情况时，检测NAG活性是诊断中的一项有价值的工具，也有助于预后判断。