Jones Hendree E, O'Grady Kevin, Dahne Jennifer, Johnson Rolley, Lemoine Laetitia, Milio Lorriane, Ordean Alice, Selby Peter
Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA.
Am J Drug Alcohol Abuse. 2009;35(3):151-6. doi: 10.1080/00952990902825413.
Empirical evidence is needed to guide adequate postpartum pain relief of methadone and buprenorphine stabilized patients.
To first determine the adequacy of pain control using non-opioid and opioid medication in participants stabilized on buprenorphine or methadone before a vaginal delivery. Second, to compare the amount of non-opioid and opioid medication needed for adequate pain control for buprenorphine-and methadone-maintained patients during the immediate postpartum period.
Pain control adequacy and amount of non-opioid and opioid medication needed in buprenorphine- (n = 8) and methadone-maintained (n = 10) patients over the first five days postpartum were examined.
Pain ratings and number of opioid medication doses decreased over time in both medication groups. While the buprenorphine and methadone groups began with similar mean daily ibuprofen (IB) doses, the buprenorphine group decreased its IB use, while the methadone group increased its IB use.
Patients treated daily with either buprenorphine or methadone can have adequate pain control postpartum with opioid medication and IB. Pain control is dependent on the opioid-agonist medication in use at delivery, and must be individualized.
需要实证依据来指导对使用美沙酮和丁丙诺啡且病情稳定的患者进行充分的产后疼痛缓解治疗。
首先确定在阴道分娩前,使用非阿片类和阿片类药物对丁丙诺啡或美沙酮维持治疗的参与者进行疼痛控制的充分性。其次,比较丁丙诺啡和美沙酮维持治疗的患者在产后即刻期间实现充分疼痛控制所需的非阿片类和阿片类药物用量。
对产后头五天内丁丙诺啡维持治疗的患者(n = 8)和美沙酮维持治疗的患者(n = 10)的疼痛控制充分性以及所需的非阿片类和阿片类药物用量进行了检查。
两个药物治疗组的疼痛评分和阿片类药物剂量数均随时间下降。虽然丁丙诺啡组和美沙酮组开始时的每日布洛芬(IB)平均剂量相似,但丁丙诺啡组减少了IB的使用量,而美沙酮组增加了IB的使用量。
每天接受丁丙诺啡或美沙酮治疗的患者在产后使用阿片类药物和IB可实现充分的疼痛控制。疼痛控制取决于分娩时使用的阿片类激动剂药物,且必须个体化。