Arshad Nuzhat, Hashim Jamshed, Kappe C Oliver
Christian Doppler Laboratory for Microwave Chemistry (CDLMC) and Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, A-8010 Graz, Austria.
J Org Chem. 2009 Jul 17;74(14):5118-21. doi: 10.1021/jo900848s.
The Pd-catalyzed cross-coupling of cyclic thioamides and thioureas with alkenylboronic acids, vinyl- and (het)arylstannanes, and arylsiloxanes in the presence of stoichiometric amounts of a Cu(I) cofactor is described. The desulfitative C-C cross-coupling protocol of the Liebeskind-Srogl type is performed under neutral conditions and can be applied to a range of heterocyclic structures with embedded thioamide fragments. Employing controlled microwave irradiation at 100 degrees C utilizing either a single-mode reactor or a multimode parallel reaction platform, cross-couplings can generally be completed within 1-3 h and proceed in good yields.
描述了在化学计量的Cu（I）辅助因子存在下，钯催化环状硫代酰胺和硫脲与烯基硼酸、乙烯基和（杂）芳基锡烷以及芳基硅氧烷的交叉偶联反应。Liebeskind-Srogl型脱硫C-C交叉偶联反应在中性条件下进行，可应用于一系列含有硫代酰胺片段的杂环结构。利用单模反应器或多模平行反应平台在100℃下进行受控微波辐射，交叉偶联反应通常可在1-3小时内完成，产率良好。
