Corrigan F M, Van Rhijn A G, Ijomah G, McIntyre F, Skinner E R, Horrobin D F, Ward N I
Argyll and Bute Hospital, Lochgilphead, UK.
Prostaglandins Leukot Essent Fatty Acids. 1991 Aug;43(4):229-38. doi: 10.1016/0952-3278(91)90035-4.
Serum elements and fatty acids of red cell and plasma phospholipids, cholesterol esters and high density lipoproteins, were studied in patients with Alzheimer's disease (SDAT) and with multi-infarct dementia (MID). Increased 20:4n6 in MID was the finding most consistent in the different tissues. The red cell phospholipids were more unsaturated in MID than in SDAT but in SDAT the plasma phospholipids were more saturated. Serum Al, Sn and V concentrations were higher in SDAT than in MID while serum Mn concentrations were higher in MID. Sn and V correlated negatively with the unsaturation index of the red cell phospholipids and Sn showed a striking pattern of correlations with the red cell phospholipid fatty acids in SDAT: it was significantly positively correlated with 16:0 and 18:1n-9 and negatively correlated with 20 and 22 carbon n-3 and n-6 essential fatty acids. Since we have shown elevated tin levels in patients with Alzheimer's disease, and since organic tin compounds given to animals produce a syndrome with similarities to Alzheimer's disease, there is a need for investigation of the role of tin in lipid metabolism in dementia.
对患有阿尔茨海默病（SDAT）和多发梗死性痴呆（MID）的患者的血清元素、红细胞和血浆磷脂中的脂肪酸、胆固醇酯以及高密度脂蛋白进行了研究。MID患者中20:4n6升高是在不同组织中最一致的发现。MID患者的红细胞磷脂比SDAT患者的更不饱和，但SDAT患者的血浆磷脂更饱和。SDAT患者血清中铝、锡和钒的浓度高于MID患者，而MID患者血清锰的浓度更高。锡和钒与红细胞磷脂的不饱和指数呈负相关，并且在SDAT患者中，锡与红细胞磷脂脂肪酸呈现出显著的相关性模式：它与16:0和18:1n-9显著正相关，与20碳和22碳的n-3和n-6必需脂肪酸呈负相关。由于我们已表明阿尔茨海默病患者体内锡水平升高，并且给动物注射有机锡化合物会产生与阿尔茨海默病相似的综合征，因此有必要研究锡在痴呆症脂质代谢中的作用。
