Brandeis R, Sapir M, Kapon Y, Borelli G, Cadel S, Valsecchi B
Department of Pharmacology, Israel Institute for Biological Research, Ness-Ziona.
Pharmacol Biochem Behav. 1991 Jun;39(2):297-304. doi: 10.1016/0091-3057(91)90183-3.
This study evaluated the ability of the selective MAO-B inhibitor, L-deprenyl, to reverse cognitive impairments appearing in aged rats, using the reference memory, Morris Water Maze paradigm. L-Deprenyl significantly improved learning and memory deficits associated with old age in doses of 1.25 and 5 mg/kg PO (escape latency measure) and doses of 1.25, 2.5 and 5 mg/kg PO (path length measure). L-Deprenyl also improved reversal learning impairments in doses of 1.25, 2.5 and 5 mg/kg PO, as expressed by the escape latency measure. The data suggest that L-deprenyl possesses potential cognitive enhancement abilities probably due to an increase in dopaminergic activity.
本研究采用参考记忆莫里斯水迷宫范式，评估了选择性单胺氧化酶-B抑制剂L-司来吉兰逆转老年大鼠出现的认知障碍的能力。L-司来吉兰以1.25和5mg/kg口服剂量（逃避潜伏期测量）以及1.25、2.5和5mg/kg口服剂量（路径长度测量）显著改善了与老年相关的学习和记忆缺陷。L-司来吉兰以1.25、2.5和5mg/kg口服剂量，通过逃避潜伏期测量显示，还改善了逆向学习障碍。数据表明，L-司来吉兰可能由于多巴胺能活性增加而具有潜在的认知增强能力。
