Caille Vincent, Ehrmann Stephan, Boissinot Eric, Perrotin Dominique, Diot Patrice, Dequin Pierre-François
INSERM U-618, Université François Rabelais, 37000 Tours, France.
J Aerosol Med Pulm Drug Deliv. 2009 Sep;22(3):255-61. doi: 10.1089/jamp.2008.0718.
The fraction of inspired oxygen (FiO(2)) during oxygen-driven jet nebulization is unknown. In the case of air-driven jet nebulization, oxygen is often added through a nasal device, and again, the FiO(2) is unknown. The aim of this experimental study was to measure FiO(2) during oxygen- and air-driven jet nebulization, oxygen being added through a nasal device, and to compare the values observed with those measured during standard oxygen therapy.
An endotracheal tube was inserted into the distal tracheal extremity of a cadaveric head and neck specimen and connected to a pump, simulating different respiratory patterns. FiO(2) was measured using an electrochemical oxygen analyzer under different nebulization and oxygen delivery conditions. Variables were compared using canonical analysis and analysis of simple and multiple variance.
FiO(2) was significantly influenced by the mode of oxygen delivery (p = 0.001). The highest FiO(2) was observed when oxygen was delivered via a nasopharyngeal catheter associated with air-driven jet nebulization. For oxygen flow rates of 12 and 15 L/min, a nasal cannula combined with air-driven jet nebulization resulted in a similar FiO(2). The FiO(2) was significantly lower in the case of oxygen-driven jet nebulization. The FiO(2) decreased with increasing respiratory rate (p < 0.001) and tidal volume (p < 0.001).
Oxygen delivery through a nasal device during air-driven jet nebulization significantly increases the FiO(2), whereas oxygen-driven jet nebulization dramatically decreases FiO(2) compared with standard oxygen therapy.
氧驱动喷射雾化期间的吸入氧分数（FiO₂）尚不清楚。在空气驱动喷射雾化的情况下，氧气通常通过鼻装置添加，同样，FiO₂也不清楚。本实验研究的目的是测量氧驱动和空气驱动喷射雾化期间（通过鼻装置添加氧气时）的FiO₂，并将观察到的值与标准氧疗期间测得的值进行比较。
将气管内导管插入尸体头颈部标本的气管远端，并连接到泵，模拟不同的呼吸模式。在不同的雾化和氧气输送条件下，使用电化学氧分析仪测量FiO₂。使用典型分析以及单因素和多因素方差分析对变量进行比较。
FiO₂受氧气输送方式的显著影响（p = 0.001）。当通过与空气驱动喷射雾化相关的鼻咽导管输送氧气时，观察到最高的FiO₂。对于12 L/min和15 L/min的氧流量，鼻导管结合空气驱动喷射雾化产生的FiO₂相似。在氧驱动喷射雾化的情况下，FiO₂显著较低。FiO₂随着呼吸频率（p < 0.001）和潮气量（p < 0.001）的增加而降低。
与标准氧疗相比，空气驱动喷射雾化期间通过鼻装置输送氧气可显著提高FiO₂，而氧驱动喷射雾化则显著降低FiO₂。
