Department of Neurology, Papageorgiou Regional General Hospital, Thessaloniki, Greece.
Med Hypotheses. 2009 Nov;73(5):781-7. doi: 10.1016/j.mehy.2009.04.021. Epub 2009 May 24.
The human central nervous system (CNS) is targeted by different pathogens which, apart from pathogens' intranasal inoculation or trafficking into the brain through infected blood cells, may use a distinct pathway to bypass the blood-brain barrier by using the gastrointestinal tract (GIT) retrograde axonal transport through sensory or motor fibres. The recent findings regarding the enteric nervous system (often called the "little brain") similarities with CNS and GIT axonal transport of infections resulting in CNS neuroinflammation are mainly reviewed in this article. We herein propose that the GIT is the vulnerable area through which pathogens (such as Helicobacter pylori) may influence the brain and induce multiple sclerosis pathologies, mainly via the fast axonal transport by the afferent neurones connecting the GIT to brain.
人类中枢神经系统（CNS）是多种病原体的靶标，除了病原体经鼻腔接种或通过感染的血细胞进入大脑之外，病原体还可能通过利用感觉或运动纤维的胃肠道（GIT）逆行轴突运输，通过独特的途径绕过血脑屏障。本文主要综述了最近关于肠神经系统（常被称为“小大脑”）与 CNS 的相似性以及感染导致 CNS 神经炎症的 GIT 轴突运输的发现。我们在此提出，GIT 是病原体（如幽门螺杆菌）可能影响大脑并引发多发性硬化症病理的脆弱区域，主要是通过连接 GIT 与大脑的传入神经元的快速轴突运输。
