Liang Mingyu
Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
Physiol Genomics. 2009 Jul 9;38(2):113-5. doi: 10.1152/physiolgenomics.00080.2009. Epub 2009 May 26.
Systems molecular medicine is the science of combining systems biology with molecular analysis and intervention to address clinically relevant questions. MicroRNAs (miRNAs) appear particularly suitable to serve as hubs of regulatory networks underlying complex diseases. Clear experimental evidence for coordinated regulation of a large number of genes by miRNAs, however, is still rare. It leaves open several fundamental questions that are important for determining the value of miRNA in complex regulatory networks and in systems molecular medicine. Physiological genomics is a powerful approach for addressing these open questions.
系统分子医学是一门将系统生物学与分子分析及干预相结合以解决临床相关问题的科学。微小RNA（miRNA）似乎特别适合作为复杂疾病潜在调控网络的枢纽。然而，关于miRNA对大量基因进行协同调控的确切实验证据仍然很少。这留下了几个基本问题，这些问题对于确定miRNA在复杂调控网络和系统分子医学中的价值至关重要。生理基因组学是解决这些未决问题的有力方法。
