Liang Mingyu, Liu Yong, Mladinov Domagoj, Cowley Allen W, Trivedi Hariprasad, Fang Yi, Xu Xialian, Ding Xiaoqiang, Tian Zhongmin
Dept. of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Am J Physiol Renal Physiol. 2009 Sep;297(3):F553-8. doi: 10.1152/ajprenal.00045.2009. Epub 2009 Apr 1.
MicroRNA (miRNA) has emerged rapidly as a major new direction in many fields of research including kidney and blood pressure research. A mammalian genome encodes several hundred miRNAs. These miRNAs potentially regulate the expression of thousands of proteins. miRNA expression profiles differ substantially between the kidney and other organs as well as between kidney regions. miRNAs may be functionally important in models of diabetic nephropathy, podocyte development, and polycystic disease. miRNAs may be involved in the regulation of arterial blood pressure, including possible involvement in genetic elements of hypertension. Studies of miRNAs could generate diagnostic biomarkers for kidney disease and new mechanistic insights into the complex regulatory networks underlying kidney disease and hypertension. Further progress in the understanding of miRNA biogenesis and action and technical improvements for target identification and miRNA manipulation will be important for studying miRNAs in renal function and blood pressure regulation.
微小RNA（miRNA）已迅速成为包括肾脏和血压研究在内的许多研究领域的一个主要新方向。哺乳动物基因组编码数百种miRNA。这些miRNA可能调控数千种蛋白质的表达。肾脏与其他器官之间以及肾脏不同区域之间的miRNA表达谱存在很大差异。miRNA在糖尿病肾病、足细胞发育和多囊性疾病模型中可能具有重要功能。miRNA可能参与动脉血压的调节，包括可能参与高血压的遗传因素。对miRNA的研究可以产生肾脏疾病的诊断生物标志物，并为肾脏疾病和高血压潜在的复杂调控网络提供新的机制性见解。在理解miRNA生物合成和作用方面取得进一步进展，以及在靶标识别和miRNA操作方面的技术改进，对于研究miRNA在肾功能和血压调节中的作用至关重要。
